- What is it?
- What is it for?
- Who has the good stuff?
- Is it safe?
- And things to avoid!
CBD or Cannabidiol is only one of more than 85 known active Cannabinoids in Marijuana. It makes up a considerable percenatage of the plant's extract. CBD is thought to be more medicinal than THC, the major psychoactive in Cannabis Sativa and Indica.
Cannabidiol has a low affinity for CB1 and CB2 receptors but acts as an indirect antagonist of their agonists. Initial appearance suggests cannabidiol may reduce the effects of THC, however it may potentiate THC's effects by increasing CB1 receptor density or through another CB1.pathway. By these means, it should extend and enhance the effects of THC via inhibition of the cytochrome P-450-3A and 2C enzymes. An important note is that the enhancing effects of CBD on THC seem to be directly related to the ratio of CBD to THC. Thus, way more CBD does not necessarily mean more enhancement. Research suggests that too much CBB in relation to THC can have overall diminutive effects.
Recently, it was found to be an antagonist at the putative new cannabinoid receptor,GPR55, a GPCR expressed in the caudate nucleus and putamen. Cannabidiol has also been shown to act as a 5-HT1A receptor partial agonist, an action which may be involved in its antidepressant, anxiolytic, and neuroprotective effects. Cannabidiol is an allosteric modulator of μ and δ-opioid receptors. In plain English, this means that using opiods and opiates WILL inhibit the effects of Marijuana. Cannabidiol's pharmacological effects have also been attributed to PPAR-γ receptor agonism and intracellular calcium release which is thought to have positive cardiovascular effects.
CBD increases levels of endocannabinoids, such as anandamide, produced by the body via inhibition of FAAH.
Who Has The Good CBD ?
CBD has actual efficacy for treating everything from pain, to neurological conditions and alot in between. This has made it a prime target for inferior products, fakes and scams!
Watch out for:
- anything made from seeds
- any product without an independent Laboratory analysis and breakdown
- any product without specific dosage levels of CBD
- ANYTHING "too good to be true"
- Bitcoins on the clearnet (if your on the deep net however, bitcoin is the BEST way to go. You can truly find excellent, legal CBD on some of the markets - this is a great route to go the famous AC/DC , Charlotte's Web, and the Rick Simpson oil are all readily available and pure, with solid customer reviews! ). Go to clearnet site www.deepnetfinds.com for info.